Skin & Aesthetics · Harley Street
Polynucleotides & Regenerative Skin Treatments in London
Regenerative injectables that help the skin repair itself, improving quality, firmness and the delicate under-eye area.
Finance available on the full cost, 0% APR up to £2,000 with Klarna (subject to status)
Polynucleotides are regenerative injectable treatments made from purified DNA fractions, most often derived from salmon or trout. They work with your skin rather than filling it, supporting the skin’s own repair processes to improve hydration, elasticity and texture over a short course. They are especially popular for the thin, delicate skin around the eyes.
Alongside polynucleotides, advanced regenerative skin treatments aim to refresh tired, crepey or ageing skin by supporting cellular renewal. Treatments at the clinic are priced from a private consultation, where we confirm what genuinely suits your skin.
What do polynucleotides do for the skin?
Polynucleotides act as a signal that supports the skin’s natural repair and renewal. Over a course, people typically see improved hydration, better elasticity and a smoother, healthier look. They are often chosen for the under-eye area, where they can soften a tired, hollow or crepey appearance, and for overall skin quality on the face and neck.
How many polynucleotide sessions will I need?
A typical course is two to three sessions spaced around two to three weeks apart, followed by maintenance every few months. Because the treatment works by supporting repair, the improvement builds gradually rather than appearing at once. We tailor the number of sessions to your skin and goals at consultation.
What concerns do polynucleotides help?
Polynucleotides are used to improve overall skin quality: texture, tone, hydration and firmness, as well as the delicate under-eye area and some scarring. Rather than adding volume, they work with the skin to support repair and renewal, so the change is natural and builds over time.
Are polynucleotides right for me?
They suit people who want to improve the health and resilience of their skin rather than reshape the face. As with any treatment, we assess your skin and your goals in person first, and explain honestly whether polynucleotides, another approach, or a combination is the better fit.
Treatments & pricing
Exosome – Skin Renewal Injections – Exodiamond
£450View treatment →
Exosome – Hair & Scalp Revitalisation Injections – Exodiamond
£450View treatment →
Eye Rejuvenation – Brightening Eye Complex – MesoEye C71
£350View treatment →
Polynucleotides – Plinest polynucleotide
£450View treatment →
Polynucleotides – Nucleofill Hydrating Booster
£450View treatment →
Prices are a guide. Your treatment is confirmed at a private consultation.
Find your treatment
Which skin treatment is right for you?
Tell us your main concern for a starting point, then confirm the right plan at a free consultation.
What is your main concern?
Frequently asked questions
Is Rejuran a polynucleotide treatment?
Yes. Rejuran is one of several brand names for polynucleotide treatments derived from purified DNA fractions. There are a number of polynucleotide products available, and the suitable one for you is chosen at consultation based on your skin, the area treated and your goals.
When will I see results from polynucleotides?
Results build gradually. Many people notice improved hydration and a fresher look within two to four weeks, with firmness and texture continuing to improve over the following weeks as the skin remodels. The effect strengthens across a course and is maintained with periodic top-ups.
Is there downtime with polynucleotides?
Downtime is usually minimal. You may have small injection points, mild redness, slight swelling or occasional bruising for a day or two, particularly under the eyes. We advise avoiding make-up, alcohol and the gym for the rest of the day, and give tailored aftercare to help everything settle.
Do polynucleotides hurt?
Most people find the treatment comfortable. Fine needles are used, with numbing where helpful, and sessions are short. Some redness or small bumps for a day or so are normal and settle quickly.
How long do the results last?
Because polynucleotides work by gradually improving the skin, results build over a course and are then maintained with occasional top-ups. We explain the likely course and maintenance for your skin at consultation.
Speak to our team
Every treatment begins with a free, no-obligation consultation at 19 Harley Street. We assess you in person and give honest advice on what suits you.
Medically reviewed by Dr Sumeyye Yuksel, MBBS · 24 July 2026